Back to Hart Beat

The Hart Of The Company

Product in Focus: Fiix Test Kit

By Ellie Nixon | 28th July 2021

The product in focus this week is the Fiix Test Kit.

Hart Bio has been a provider of products used for INR testing for many years and Fiix represents the next generation of laboratory Prothrombin Time (PT) tests offering enhanced performance and superior patient outcomes.

How it works:

Thrombosis is the process of a blood clot, also known as a thrombus, forming in a blood vessel. This clot can block or obstruct blood flow in the affected area, as well as cause serious complications if the clot moves to a crucial part of the circulatory system, such as the brain or the lungs. (1) The risk of thrombosis is mainly associated with Factor II and X levels.

Factor VII is highly variable via diet and exercise and has a big influence on regular International Normalized Ratio (INR), however less correlated to actual bleeding and thrombosis risk.

Fiix negates the influence of Factor VII, therefore giving a better prediction of risk to the patient and offering enhanced performance and superior patient outcomes. This PT measurement provides a ratio known as the International Normalised Ratio (INR) which is used to assign the daily dose of warfarin for paitents. Patients using warfarin require regular monitoring by attending clinics quite often organsied by their local hospital where a small sample of blood is analysed. 

The reagent is fully compliant for use on both optical and mechanical coagulometers, semi-automated or automated.


What it contains:

Fiix™ Test Kit contains the following:

5 x 1 mL lyophilised Fiix plasma reagent, 5 x 3.5 mL PT reagent and 5 x 3.5 mL Imidazole buffer

Main features:

  • The Fiix test is only sensitive to reductions in the factors responsible for VKA antithrombotic effect, namely factors II and X
  • Fiix™ed warfarin has a stabilized anticoagulation effect
  • In atrial fibrillation patient’s warfarin managed by Fiix-NR monitoring is at least as effective as composite direct oral anticoagulants (DOACs)
  • Fiix™ed warfarin safely reduces thromboembolism by half compared to standard INR monitoring
  • Fiix™ed warfarin is a “NOAC” (new oral anticoagulant)
  • Warfarin instability can be Fiix™ed by replacing the PT (INR) with Fiix™-PT (Fiix™-NR) monitoring

To find out how to run a Mean PT / ISI Calibration test with Fiix, click here 

To view the Fiix kit or enquire about the product, click here