Hart Biologicals Arachidonic Acid reagent is used to diagnose platelet dysfunction, or normal platelet activity in human platelet rich plasma or whole blood.
The platelet aggregation test measures the rate and degree to which dispersed platelets in a sample of platelet rich plasma (PRP) or anti-coagulated whole blood forms clumps (aggregates) after the addition of a substance that normally stimulates platelet aggregation (agonist).
Arachidonic acid is a fatty acid present in the granules and membranes of human platelets. It is liberated from phospholipids and, in the presence of the enzyme cyclo-oxygenase 1 (COX-1), incorporates oxygen to form the endoperoxide prostaglandin G2 (PGG2). PGG2 is then quickly transformed to prostaglandin H2 (PGH2) which in turn is converted to thromboxane A2 a potent inducer of platelet aggregation. In vitro addition of Arachidonic acid to normal platelet rich plasma results in a burst of oxygen consumption, thromboxane formation and platelet aggregation
Hart Biologicals Arachidonic Acid Reagent is supplied as the following for reconstitution with 1.0ml distilled water:
· 1 x 1.0ml 5mg/ml Arachidonic Acid
Note: To download a copy of this Product's Instructions For Use in English, create an account by clicking 'Register' at the top right corner of this screen. Other European languages, including French, German, Spanish and Italian may be available upon request.