Hart Biologicals ADP Reagent is used to diagnose platelet dysfunction, or normal platelet activity in human platelet rich plasma or whole blood.
The platelet aggregation test measures the rate and degree to which dispersed platelets in a sample of platelet rich plasma (PRP) or anti-coagulated whole blood forms clumps (aggregates) after the addition of a substance that normally stimulates platelet aggregation (agonist).
An important mediator of platelet activation and aggregation is ADP (adenosine 5'-diphosphate) which is released from blood platelets in the vasculature upon activation by various agents, such as collagen and thrombin, and from damaged blood cells, endothelium or tissues. Activation by ADP results in the recruitment of more platelets and stabilization of existing platelet aggregates.
Hart Biologicals ADP Reagent is supplied as the following for reconstitution with 1.0ml distilled water:
· 1 x 1.0ml 0.2mM ADP
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